After adjusting for potential confounders, urinary manganese, iron, copper, zinc, cadmium, antimony and barium were identified to be negatively associated with one or more HRV parameters. ![]() The potential role of 8-iso-PGF2α in the association of urinary heavy metals with HRV was evaluated through mediation analyses. We conducted multivariable linear regression models to quantify associations between urinary 8-iso-prostaglandin-F2α (8-iso-PGF2α) and heavy metals or HRV indices. Urinary heavy metals (including lead, barium, antimony, cadmium, zinc, copper, iron and manganese), urinary 8-iso-prostaglandin-F2α levels (common biomarker for lipid peroxidation) and HRV indices (SDNN, r-MSSD, low frequency, high frequency and total power) were measured among 3022 participants. ![]() We performed a cross-sectional study using baseline data of Wuhan-Zhuhai cohort. In this research, we investigated the possible role of lipid peroxidation in the associations between urinary heavy metals and HRV. However, possible pathway of such association remains unclear. ![]() Exposure to heavy metals was reported to be associated with heart rate variability (HRV) alteration.
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